Cyclooxygenase-2 Polymorphisms and Pancreatic Cancer Susceptibility

Ozhan G., Lochan R., Leathart J. B. S., Charnley R., Daly A. K.

PANCREAS, cilt.40, sa.8, ss.1289-1294, 2011 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 8
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1097/mpa.0b013e31821fcc3b
  • Dergi Adı: PANCREAS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1289-1294
  • Anahtar Kelimeler: pancreatic cancer, COX-2, SNPs, LUNG-CANCER, COX-2 GENE, FUNCTIONAL POLYMORPHISMS, BREAST-CANCER, ESOPHAGEAL ADENOCARCINOMA, INFLAMMATORY RESPONSE, COMMON POLYMORPHISM, CHINESE POPULATION, CIGARETTE-SMOKING, CELL-CARCINOMA
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objectives: DNA sequence variants in the cyclooxygenase-2 (COX-2) gene may lead to altered COX-2 production and/or activity, resulting in interindividual differences in susceptibility to pancreatic cancer. To test this hypothesis, we investigated the relationship between polymorphisms in the COX-2 gene and the risk of pancreatic cancer in a European population.