Cyclooxygenase-2 Polymorphisms and Pancreatic Cancer Susceptibility

Ozhan G., Lochan R., Leathart J. B. S., Charnley R., Daly A. K.

PANCREAS, vol.40, no.8, pp.1289-1294, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 8
  • Publication Date: 2011
  • Doi Number: 10.1097/mpa.0b013e31821fcc3b
  • Journal Name: PANCREAS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1289-1294
  • Keywords: pancreatic cancer, COX-2, SNPs, LUNG-CANCER, COX-2 GENE, FUNCTIONAL POLYMORPHISMS, BREAST-CANCER, ESOPHAGEAL ADENOCARCINOMA, INFLAMMATORY RESPONSE, COMMON POLYMORPHISM, CHINESE POPULATION, CIGARETTE-SMOKING, CELL-CARCINOMA
  • Istanbul University Affiliated: Yes

Abstract

Objectives: DNA sequence variants in the cyclooxygenase-2 (COX-2) gene may lead to altered COX-2 production and/or activity, resulting in interindividual differences in susceptibility to pancreatic cancer. To test this hypothesis, we investigated the relationship between polymorphisms in the COX-2 gene and the risk of pancreatic cancer in a European population.