Long-term effects of COVID-19 on lungs and the clinical relevance: a 6-month prospective cohort study

Tuncer G., Geyiktepe-Guclu C., Surme S., Canel-Karakus E., Erdogan H., Bayramlar O. F., ...Daha Fazla

Future Microbiology, cilt.18, sa.4, ss.185-198, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 4
  • Basım Tarihi: 2023
  • Doi Numarası: 10.2217/fmb-2022-0121
  • Dergi Adı: Future Microbiology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.185-198
  • Anahtar Kelimeler: chest CT, COVID-19, follow-up, pulmonary function, residual disease
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: We aimed to explore the prevalence of prolonged symptoms, pulmonary impairments and residual disease on chest tomography (CT) in COVID-19 patients at 6 months after acute illness. Methods: In this prospective, single-center study, hospitalized patients with radiologically and laboratory-confirmed COVID-19 were included. Results: A high proportion of the 116 patients reported persistent symptoms (n = 54; 46.6%). On follow-up CT, 33 patients (28.4%) demonstrated residual disease. Multivariate analyses revealed that only neutrophil-to-lymphocyte ratio was an independent predictor for residual disease. Conclusion: Hospitalized patients with mild/moderate COVID-19 still had persistent symptoms and were prone to develop long-term pulmonary sequelae on chest CT. However, it did not have a significant effect on long-term pulmonary functions.