Might there be a link between mannose binding lectin and vitiligo?

Onay H., Pehlivan M., Alper S., Özkınay F., PEHLİVAN S.

EUROPEAN JOURNAL OF DERMATOLOGY, cilt.17, sa.2, ss.146-148, 2007 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 2
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1684/ejd.2007.0128
  • Dergi Adı: EUROPEAN JOURNAL OF DERMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.146-148
  • Anahtar Kelimeler: MBL, vitiligo, susceptibility, polymorphism, SYSTEMIC-LUPUS-ERYTHEMATOSUS, RHEUMATOID-ARTHRITIS, GENE POLYMORPHISMS, SJOGRENS-SYNDROME, DEFICIENCY, MBL
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Mannose binding lectin (MBL) is a calcium dependent lectin that causes predisposition to infections and autoimmune diseases. This study aimed to examine the presence of any association between MBL2 gene variants and vitiligo. Codon 54 (allele B) and codon 57(allele C) polymorphisms in the exon 1 of the MBL2 gene were investigated in samples belonged to 50 healthy controls and 40 patients diagnosed as vitiligo. The PCRRFLP method was used to investigate the polymorphisms in the MBL2 gene. Codon 57 polymorphism was not detected in any of the subjects from either group. The frequencies of low level MBL2 genotypes for codon 54 (AB and 1313) polymorphisms were found to be significantly higher in the patient group compared to controls (37.5% vs. 6%) (p < 0.001). B allele frequency was also significantly higher in the patient group (20%) compared to the control group (3%). These results suggested that codon 54 polymorphism in the MBL2 gene may play a role in susceptibility to vitiligo.