Effects of Tarantula cubensis Extract on Electrocardiographic and Trace Element Status in Sheep

GÖNÜL R., KOENHEMSİ L., Aydın H., Gülyaşar T., YARDİBİ H., OR M. E., ...More

İstanbul Üniversitesi Veteriner Fakültesi Dergisi, vol.41, no.1, pp.79-83, 2015 (SCI-Expanded)

  • Publication Type: Article / Article
  • Volume: 41 Issue: 1
  • Publication Date: 2015
  • Journal Name: İstanbul Üniversitesi Veteriner Fakültesi Dergisi
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.79-83
  • Istanbul University Affiliated: Yes


The purpose of this research was to investigate the acute effects of Tarantula cubensis
extract (Theranekron, 1:100/D2, Richter Pharma, Austria) on some serum enzymes and
trace elements, and the cardiovascular system in sheep. Seven sheep (age 6 months, 35±10
kg) were used in this study. Theranekron was applied in 6 ml doses subcutaneously. It was
determined that in the serum Urea, Creatinin, ALT, ALP, G-GT, LDH, Ca and P levels were
increased and T. protein, Mg, Cu, Fe, Zn and Se levels were decreased. The important
results obtained after the treatment with Theranekron on cardiovascular system were
blood pressure increases and some morphological changes in ECG. We concluded the
Theranekron treatment can cause adverse effects in sheep and further investigation of the
efficacy of Theranekron treatment is warranted.