Therapeutic apheresis for severe hypertriglyceridemia in pregnancy.
Archives of gynecology and obstetrics, cilt.287, sa.5, ss.839-43, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 287 Sayı: 5
- Basım Tarihi: 2013
- Doi Numarası: 10.1007/s00404-013-2786-z
- Dergi Adı: Archives of gynecology and obstetrics
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.839-43
- Anahtar Kelimeler: Hypertriglyceridemia, Pregnancy, Acute pancreatitis, Plasmapheresis, Double filtration apheresis, ACUTE-PANCREATITIS, CHYLOMICRONEMIA
- İstanbul Üniversitesi Adresli: Evet
Özet
During pregnancy, a progressive increase in serum triglyceride (TG) and cholesterol levels is observed whereas TG levels mostly remain < 300 mg/dl. In women with genetic forms of hypertriglyceridemia, pregnancy may cause extremely elevated TG levels leading to potentially life-threatening pancreatitis attacks and chylomicronemia syndrome. The only safe medical treatment option during pregnancy is omega-3 fatty acids, which have moderate TG lowering effects. Therapeutic apheresis could be used as primary treatment approach during pregnancy.