Treatment of high-grade glioma in children

Betul Cakir F., Kebudi R.

TURK ONKOLOJI DERGISI-TURKISH JOURNAL OF ONCOLOGY, vol.28, no.1, pp.44-50, 2013 (ESCI) identifier identifier

  • Publication Type: Article / Review
  • Volume: 28 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.5505/tjoncol.2013.873
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Page Numbers: pp.44-50
  • Keywords: Brain stem glioma, biological agents, chemotherapy, radiotherapy, high grade glioma
  • Istanbul University Affiliated: Yes


Pediatric high-grade gliomas, including glioblastoma multiforme, anaplastic astrocytoma, and diffuse intrinsic pontine glioma, are difficult to treat and are associated with an extremely poor prognosis. For several decades, radical and safe surgical resection and radiotherapy have formed the cornerstone of therapy for pediatric high-grade gliomas. However, for the majority of affected children, these modalities only provide short-term clinical benefits and disease control, with the vast majority of these patients experiencing disease progression within 2 years. The infiltrative nature and the intrinsic radio-resistance of these tumors are believed to be the major contributors to the dismal prognosis displayed by these tumors. There are no effective chemotherapeutic regimens for the treatment of these tumors, but many new treatment options are in active investigation. The current belief is that multimodal therapy holds the greatest promise for pediatric high-grade gliomas.