Mediastinal adipose tissue expresses a pathogenic profile of 11 beta-hydroxysteroid dehydrogenase Type 1, glucocorticoid receptor, and CD68 in patients with coronary artery disease

Atalar F., Gormez S., Caynak B., Akan G., Tanriverdi G., Bilgic-Gazioglu S., ...More

CARDIOVASCULAR PATHOLOGY, vol.22, no.3, pp.183-188, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.1016/j.carpath.2012.07.006
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.183-188
  • Keywords: Mediastinal adipose tissue, Subcutaneous adipose tissue, 11 beta hydroxysteroid dehydrogenase, Glucocorticoid receptor, Coronary artery disease, VISCERAL ABDOMINAL FAT, CARDIOVASCULAR-DISEASE, PERICARDIAL FAT, CARDIOMETABOLIC RISK, METABOLIC SYNDROME, EPICARDIAL FAT, OBESITY, HEART, INFLAMMATION, RESISTANCE
  • Istanbul University Affiliated: Yes


Objective: Cardiac visceral fat is accepted to be a new marker for cardiometabolic risk due to its association with increased cardiovascular risk factors. This study aimed to compare the expression of 11 beta hydroxysteroid dehydrogenases (11 beta-HSD)-1, glucocorticoid receptor (GCR), and CD68 in mediastinal and subcutaneous adipose tissues (MAT, and SAT, respectively) and to assess their possible relationships with the development of coronary artery disease (CAD).