Akademik Veri Yönetim Sistemi
EANM 2022 Congress, Barcelona, İspanya, 15 - 19 Ekim 2022, ss.671
Aim/Introduction: Fibroblast Activation Protein(FAP) targeted 68GaFAPI PET-CT has been introduced recently in diagnosis of malignant tumors with increased FAP expression.However,FAP expression can be detected in several benign pathologies which causes incidental non-tumoral uptake.Here in,we present incidental cardiac uptake detected in 68Ga-FAPI PET-CT related to cardiovascular diseases. Materials and Methods: Case 1:
ast Activation Protein(FAP) targeted 68GaFAPI PET-CT has been introduced recently in diagnosis of malignant tumors with increased FAP expression.However,FAP expression can be detected in several benign pathologies which causes incidental non-tumoral uptake.Here in,we present incidental cardiac uptake detected in 68Ga-FAPI PET-CT related to cardiovascular diseases.
Materials and Methods: Case 1:
66 years old male with initially diagnosed colangiocarcinoma was performed 68Ga-FAPI PET-CT for staging.Increased FAPI uptake(SUVmax: 3.84) in anterior and inferior wall of left ventricle was detected.Patient had hypertension and COPD.Echocardiography defned hypokinesia in septum and inferior wall.Coronary angiography determined 70% stenosis in LAD and stent was implanted,in addition to 40% stenosis in proximal and mid RCA.Angiography results were correlated with cardiac FAPI uptake which reveals that fbroblast related infammatory processes1 in ischemic myocardium can cause incidental cardiac uptake.Case 2:69 years old male with smoking and peripheral artery disease history was diagnosed anterior MI and underwent CAG in April 2020.Stent was implanted due to %95 stenosis in proximal LAD.Mid RCA and Cx was also %80 stenotic but no intervention was performed.Echocardiography revealed that apex, septum and anterior wall were akinetic.In follow-up, the patient was diagnosed hypopharynx SCC and underwent 68Ga-FAPI PET-CT study for staging.Increased FAPI uptake(SUV max: 3.47) was detected in apex, septum and anterior wall.Myocard perfusion scintigraphy(MPS) showed no signifcant ischemia,only hypokinesia was detected in anterior wall.FAPI uptake in hypokinetic anterior wall was interpreted as a sign of ventricular remodelling2 in patient with anterior MI history.Case 3: 65 years old male with type 2 diabetes mellitus,hypertension and chronic renal failure had history of RIMA-LAD and LIMA-OM bypass in 2001.Patient was diagnosed nasopharenx carcinoma In April 2021 and underwent 68Ga-FAPI PET-CT for staging.Global increased cardiac FAPI uptake(SUVmax: 7.5) was defned and MPS was planned.MPS determined post MI fndings in anterior and inferior wall, ischemia in lateral and anterolateral wall and global hypokinesia.Cardiac FAPI uptake was related to ventricular remodeling and ischemia3 .
Results: Our cases demonstrate that incidental cardiac FAPI uptake was related to cardiovascular diseases and further cardiologic evaluation is valuable in terms of cardiac event risk in patients with incidental cardiac FAPI uptake.
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Ga-68 FAPI PET imaging as a potential novel biomarker of cardiac
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