The dose-related effects of Dexmedetomidine on renal functions and serum neutrophil gelatinase-associated lipocalin values after coronary artery bypass grafting: a randomized, triple-blind, placebo-controlled study


Balkanay O. O. , Goksedef D., Omeroglu S. N. , Ipek G.

INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, vol.20, no.2, pp.209-214, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.1093/icvts/ivu367
  • Title of Journal : INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
  • Page Numbers: pp.209-214

Abstract

OBJECTIVES: Acute kidney failure after coronary artery bypass grafting (CABG) is a serious complication that increases morbidity and mortality rates. Early detection and prevention of this complication are very important. A novel biomarker named neutrophil gelatinaseassociated lipocalin (NGAL) can play an important role in early diagnosis of acute kidney injury. Recent studies on the favourable effects of Dexmedetomidine on cardiac surgery have been published. The aim of this study is to investigate whether there is a dose-dependent positive effect of Dexmedetomidine on neutrophil gelatinase-associated lipocalin levels and renal functions when used after CABG.