Investigation of Ongoing Denervation and Reinnervation in Amyotrophic Lateral Sclerosis by Using Concentric Needle Electrode with Single Fiber Electromyography Method Amyotrofik Lateral Sklerozda Devam Eden Denervasyon ve Reinnervasyonun Tek Lif Elektromiyografi Yöntemi ile Konsantrik İğne Elektrodu Kullanılarak İncelenmesi

Bekdik P., BASLO M. B.

Noropsikiyatri Arsivi, cilt.60, sa.4, ss.298-303, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 60 Sayı: 4
  • Basım Tarihi: 2023
  • Doi Numarası: 10.29399/npa.28162
  • Dergi Adı: Noropsikiyatri Arsivi
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, Psycinfo, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.298-303
  • Anahtar Kelimeler: Amyotrophic lateral sclerosis, concentric needle electrode, neuromuscular jitter, peak number, single fiber electromyography
  • İstanbul Üniversitesi Adresli: Evet

Özet

Introduction: The aim of this study is to demonstrate the conduction disturbance at the neuromuscular junction in a cranial muscle by measuring jitter with a concentric needle (CN) electrode in the diagnosis of Amyotrophic Lateral Sclerosis (ALS) and to investigate the utility of evaluating the peak number as an ongoing reinnervation marker. Method: Twelve patients diagnosed with ALS were included in this study. Single fiber electromyography (SFEMG) was performed using a CN electrode during the voluntary contraction of the right extensor digitorum communis (EDC) and left frontalis muscles. Results: In SFEMG from the right EDC muscle, the mean jitter value was high in all of them. The average jitter calculated in EDC muscles was 57.76±24.17 µs. The mean jitter value in the frontal muscles was 28.91±10.21 µs. In all patients, the number of CN electrode peaks was more than 4 in the EDC muscle and above 4 in 91.67% of the frontal muscle. Conclusion: Detection of high jitter in SFEMG examination indicates that the examined muscle undergoes a denervation-reinnervation process in the case of increased peak number values. When such a determination is made in the extremity muscles, it becomes important for the diagnosis of ALS.