The association of CMV infection with bacterial and fungal infections in hematopoietic stem cell transplant recipients: a retrospective single-center study.

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Öksüz L., Hi Ndi Lerden İ. Y., Erci Yestepe M., Önel M., Hi Ndi Lerden F., Çağatay A., ...More

The new microbiologica, vol.45, no.1, pp.40-50, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 1
  • Publication Date: 2022
  • Journal Name: The new microbiologica
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.40-50
  • Istanbul University Affiliated: Yes


This study aims to evaluate the probable association between CMV infection and bacterial or fungal infections in 91 consecutive adult patients who underwent autologous or allogeneic HSCT within a period of two years.

Medical records of the patients were retrospectively reviewed. Blood cultures were evaluated by automated blood culture system. A quantitative real-time polymerase chain reaction was performed to detect CMV DNA.

CMV infection and CMV disease were detected in 42 (46%)(Ng et al., 2005) and six (6.6%) patients, respectively. Of the 158 microorganisms isolated, 115 (73%) were Gram-positive bacteria. Bacteremia and fungemia developed in 55 (60%) and eight (8%) patients, respectively. Concurrent CMV infection and bacteremia were detected in 17 (18.7%) patients and concurrent CMV infection and fungal infection were detected in five (5.5%) patients. Graft versus host disease (GVHD) developed in 15 (50%) allogeneic HSCT recipients and two (2.2%) autologous HSCT recipients. Twenty-one (23%) patients including 13 (43%) allogeneic and eight (13%) autologous HSCT recipients died.

The most common infection is bacteremia, and it develops concurrently with CMV infection in approximately one-fifth of HSCT recipients. Gram-positive bacteria are more common in bacteremia. Further studies on the follow-up and treatment of infections after HSCT will improve survival rates post-HSCT.