The association of CMV infection with bacterial and fungal infections in hematopoietic stem cell transplant recipients: a retrospective single-center study.
The new microbiologica, cilt.45, sa.1, ss.40-50, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 45 Sayı: 1
- Basım Tarihi: 2022
- Dergi Adı: The new microbiologica
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.40-50
- İstanbul Üniversitesi Adresli: Evet
Özet
This study aims to evaluate the probable association
between CMV infection and bacterial or fungal infections in 91 consecutive
adult patients who underwent autologous or allogeneic HSCT within a period of
two years.
Medical records of the patients were retrospectively
reviewed. Blood cultures were evaluated by automated blood culture system. A
quantitative real-time polymerase chain reaction was performed to detect CMV
DNA.
CMV infection and CMV disease were detected in 42
(46%)(Ng et al., 2005) and six (6.6%) patients, respectively. Of the 158
microorganisms isolated, 115 (73%) were Gram-positive bacteria. Bacteremia and
fungemia developed in 55 (60%) and eight (8%) patients, respectively.
Concurrent CMV infection and bacteremia were detected in 17 (18.7%) patients
and concurrent CMV infection and fungal infection were detected in five (5.5%)
patients. Graft versus host disease (GVHD) developed in 15 (50%) allogeneic
HSCT recipients and two (2.2%) autologous HSCT recipients. Twenty-one (23%) patients
including 13 (43%) allogeneic and eight (13%) autologous HSCT recipients died.
The most common infection is bacteremia, and it
develops concurrently with CMV infection in approximately one-fifth of HSCT
recipients. Gram-positive bacteria are more common in bacteremia. Further
studies on the follow-up and treatment of infections after HSCT will improve
survival rates post-HSCT.