The efficacy of minocycline against methotrexate-induced pulmonary fibrosis in mice

Kalemci S., Dirican N., ÇETİN E., Sozen H., Uner A. G., Yaylali A., ...Daha Fazla

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, cilt.17, sa.24, ss.3334-3340, 2013 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 24
  • Basım Tarihi: 2013
  • Dergi Adı: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3334-3340
  • Anahtar Kelimeler: Methotrexate, Pulmonary fibrosis, Minocycline, NON-ANTIBIOTIC PROPERTIES, SPINAL-CORD, TETRACYCLINES, MODEL, LUNG
  • İstanbul Üniversitesi Adresli: Evet

Özet

OBJECTIVES: In addition to its antimicrobial effects, inhibitory effects of minocycline have been demonstrated, including against inflammation, apoptosis, proteolysis, angiogenesis, and tumor metastasis. In this study, we aimed to determine the beneficial effects of minocycline on lung histology and its antioxidant activity in a murine model of pulmonary fibrosis.