The efficacy of minocycline against methotrexate-induced pulmonary fibrosis in mice

Kalemci, S.; Dirican, N.; ÇETİN, Esin; Sozen, H.; Uner, A.; Yaylali, A.; Aksun, S.; Karacam, V.; Ulger, E.; Sutcu, R.; Dirican, A.

The efficacy of minocycline against methotrexate-induced pulmonary fibrosis in mice

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Kalemci S., Dirican N., ÇETİN E., Sozen H., Uner A. G., Yaylali A., ...More

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, vol.17, no.24, pp.3334-3340, 2013 (SCI-Expanded)

Publication Type: Article / Article
Volume: 17 Issue: 24
Publication Date: 2013
Journal Name: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.3334-3340
Keywords: Methotrexate, Pulmonary fibrosis, Minocycline, NON-ANTIBIOTIC PROPERTIES, SPINAL-CORD, TETRACYCLINES, MODEL, LUNG
Istanbul University Affiliated: Yes

Abstract

OBJECTIVES: In addition to its antimicrobial effects, inhibitory effects of minocycline have been demonstrated, including against inflammation, apoptosis, proteolysis, angiogenesis, and tumor metastasis. In this study, we aimed to determine the beneficial effects of minocycline on lung histology and its antioxidant activity in a murine model of pulmonary fibrosis.