Childhood Rhabdomyosarcoma of the Female Genital Tract: Association with Pathogenic DICER1 Variation, Clinicopathological Features, and Outcomes

Kebudi, Rejin; Dural, ÖZLEM; Bay, Sema; Gorgun, Ömer; Onder, SEMEN; Bilgic, MEBRURE; Yilmaz, Ismail; Iribas, AYÇA; Arndt, Carola; Harris, Anne; Field, Amanda; Schultz, Kris; Hill, D.

doi:10.1016/j.jpag.2021.01.011

Childhood Rhabdomyosarcoma of the Female Genital Tract: Association with Pathogenic DICER1 Variation, Clinicopathological Features, and Outcomes

Kebudi R., Dural O., Bay S. B., Gorgun O., Onder S., Bilgic B., ...Daha Fazla

JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY, cilt.34, sa.4, ss.449-453, 2021 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 34 Sayı: 4
Basım Tarihi: 2021
Doi Numarası: 10.1016/j.jpag.2021.01.011
Dergi Adı: JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
Sayfa Sayıları: ss.449-453
İstanbul Üniversitesi Adresli: Evet

Özet

Study Objective: Rhabdomyosarcomas (RMSs) of the female genital tract (FGT) have been recently shown to be associated with germline pathogenic variation in DICER1, which can underlie a tumor predisposition disorder. We sought to determine the incidence of a pathogenic variation in DICER1 in a cohort of RMSs of the FGT, as well as to evaluate the clinicopathological features and outcomes of the patients.