Childhood Rhabdomyosarcoma of the Female Genital Tract: Association with Pathogenic DICER1 Variation, Clinicopathological Features, and Outcomes

Kebudi, Rejin; Dural, ÖZLEM; Bay, Sema; Gorgun, Ömer; Onder, Semen; Bilgic, Mebrure; Yilmaz, Ismail; Iribas, Ayça; Arndt, Carola; Harris, Anne; Field, Amanda; Schultz, Kris; Hill, D.

doi:10.1016/j.jpag.2021.01.011

Childhood Rhabdomyosarcoma of the Female Genital Tract: Association with Pathogenic DICER1 Variation, Clinicopathological Features, and Outcomes

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Kebudi R., Dural O., Bay S. B., Gorgun O., Onder S., Bilgic B., ...More

JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY, vol.34, no.4, pp.449-453, 2021 (SCI-Expanded)

Publication Type: Article / Article
Volume: 34 Issue: 4
Publication Date: 2021
Doi Number: 10.1016/j.jpag.2021.01.011
Journal Name: JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
Page Numbers: pp.449-453
Istanbul University Affiliated: Yes

Abstract

Study Objective: Rhabdomyosarcomas (RMSs) of the female genital tract (FGT) have been recently shown to be associated with germline pathogenic variation in DICER1, which can underlie a tumor predisposition disorder. We sought to determine the incidence of a pathogenic variation in DICER1 in a cohort of RMSs of the FGT, as well as to evaluate the clinicopathological features and outcomes of the patients.