A new antibacterial diterpene from the roots of Salvia caespitosa

Ulubelen A., Oksuz S., Topcu G., Goren A., Bozok-Johansson C., Celik C., et al.

NATURAL PRODUCT LETTERS, cilt.15, ss.307-314, 2001 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 15 Konu: 5
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1080/10575630108041297
  • Sayfa Sayısı: ss.307-314


From the roots of Saliva caespitosa Montbret and Aucher ex. Bentham a new diterpene 6beta-hydroxyisopimaric acid (1) has been isolated together with four known diterpenes, one new triterpenoid, 3-acetylvergatic acid (2), as well as five known triterpenoids, two steroids and a flavone. The structures of the compounds were established by spectroscopic analyses. The isolated compounds were tested against standard bacterial strains. Only the new diterpene, 6beta-hydroxyisopimaric acid has strong activity (MIC 9 mug/ml) against S. aureus and (MIC 18 mug/ml) against S. epidermidis as well as against B. subtilis (MIC 9 mug/ml).