Slow-channel mutation in acetylcholine receptor alpha M4 domain and its efficient knockdown

Shen X., Deymeer F., Sine S. M., Engel A. G.

ANNALS OF NEUROLOGY, vol.60, no.1, pp.128-136, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 60 Issue: 1
  • Publication Date: 2006
  • Doi Number: 10.1002/ana.20861
  • Journal Name: ANNALS OF NEUROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.128-136
  • Istanbul University Affiliated: Yes

Abstract

Objective: To identify the genetic basis of a slow-channel myasthenic syndrome, characterize functional properties of the mutant receptor, and selectively silence the mutant allele.