Acetamiprid-induced Cyto- and Genotoxicity in the AR42J Pancreatic Cell Line

Kara M., Oztas E., Ozhan G.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.17, sa.5, ss.474-479, 2020 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 5
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4274/tjps.galenos.2019.89719
  • Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, International Pharmaceutical Abstracts, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.474-479
  • Anahtar Kelimeler: Acetamiprid, AR42J pancreatic cell line, cytotoxicity, genotoxicity, oxidative damage, IN-VITRO, OXIDATIVE STRESS, COMET ASSAY, LYMPHOCYTES, PESTICIDES, TOXICITY, EXPOSURE, HEALTH
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objectives: Neonicotinoid insecticides, 30% of insecticides marketed worldwide, have selective toxicity on insects through alpha 4p2 nicotinic acetylcholine receptors. Although it is known that acetamiprid exerts toxicity on several organ systems, its toxic effects on the pancreas and its mechanism of action have not been clarified yet. Therefore, in the present study, the cytotoxic and genotoxic potentials of acetamiprid on the AR42J pancreatic cell line were evaluated.