Acetamiprid-induced Cyto- and Genotoxicity in the AR42J Pancreatic Cell Line

Kara M., Oztas E., Ozhan G.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.17, no.5, pp.474-479, 2020 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 5
  • Publication Date: 2020
  • Doi Number: 10.4274/tjps.galenos.2019.89719
  • Journal Name: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, International Pharmaceutical Abstracts, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.474-479
  • Keywords: Acetamiprid, AR42J pancreatic cell line, cytotoxicity, genotoxicity, oxidative damage, IN-VITRO, OXIDATIVE STRESS, COMET ASSAY, LYMPHOCYTES, PESTICIDES, TOXICITY, EXPOSURE, HEALTH
  • Istanbul University Affiliated: Yes

Abstract

Objectives: Neonicotinoid insecticides, 30% of insecticides marketed worldwide, have selective toxicity on insects through alpha 4p2 nicotinic acetylcholine receptors. Although it is known that acetamiprid exerts toxicity on several organ systems, its toxic effects on the pancreas and its mechanism of action have not been clarified yet. Therefore, in the present study, the cytotoxic and genotoxic potentials of acetamiprid on the AR42J pancreatic cell line were evaluated.