Dental follicle mesenchymal stem cell administration ameliorates muscle weakness in MuSK-immunized mice.
Journal of neuroinflammation, cilt.12, ss.231, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 12
- Basım Tarihi: 2015
- Doi Numarası: 10.1186/s12974-015-0451-0
- Dergi Adı: Journal of neuroinflammation
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.231
- Anahtar Kelimeler: Myasthenia gravis, Muscle-specific kinase, Mesenchymal stem cells, Dendritic cells, Autoimmunity, AUTOIMMUNE MYASTHENIA-GRAVIS, TYROSINE KINASE MUSK, BONE-MARROW, CLINICAL-APPLICATIONS, SUPPRESSION, EXPRESSION, GAMMA
- İstanbul Üniversitesi Adresli: Evet
Özet
Background: Myasthenia gravis (MG) is an antibody-mediated autoimmune disease of the neuromuscular junction (NMJ), mostly associated with acetylcholine receptor (AChR) antibodies. Around 5-10 % of MG patients show antibodies to muscle-specific tyrosine kinase (MuSK). Mesenchymal stem cell (MSC) administration has been shown to ameliorate muscle weakness in the experimental autoimmune myasthenia gravis (EAMG) model induced by AChR immunization.