Investigation of the Formation of Copper(H)-Tryptophane-Aspirin Ternary Complexes

Anilanmert B., Pekin M., Apak R.

ASIAN JOURNAL OF CHEMISTRY, vol.22, no.10, pp.8060-8072, 2010 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 10
  • Publication Date: 2010
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.8060-8072
  • Istanbul University Affiliated: Yes


Formation constants and the stoichiometric composition of the potentially therapeutic complex of Cu-tryptophane-aspirin were determined potentiometrically, at 25 degrees C (+/- 1) and I = 0.11. The formation constants of binary Cu(II)-aspirin (1:2) complex, on which few and many information exist in literature, were also investigated. Distribution of species was calculated for various pH values. Cu(II)-Tryptophan-aspirin ternary complex formation was confirmed through UV and IR spectrometry and qualitative metal analysis in the precipitates. The stability constants of ternary complexes of Cu(II)-Tryp-ASA were reported, which is important for further studies on this therapeutically important ternary complex, both from the point of synthesis and commenting on its pharmacokinetics.