Research Information System
The Turkish Journal of Ear Nose and Throat, vol.35, no.1, pp.35-40, 2025 (Scopus, TRDizin)
Objective: To investigate the relationship between obstructive sleep apnoea (OSA) severity and oxygen desaturation with biomarkers including ischaemia-modified albumin (IMA), interleukin-1β (IL-1β), thiol/ disulphide homeostasis parameters, and cardiac biomarkers (BNP, NT-proBNP). Material and Methods: This cross-sectional study included 88 patients who underwent polysomnography at the Bezmialem Vakif University Sleep Laboratory. Participants were categorised into normal/mild OSA (n=36) and moderate/severe OSA (n=52) groups based on the apnoea-hypopnoea index (AHI). Blood samples were analysed for BNP, NT-proBNP, IMA, IL-1β, and thiol/disulphide homeostasis parameters. Results: The moderate/severe OSA group showed significantly higher levels of IMA (0.94±0.04 vs 0.88±0.04, p<0.001), IL-1β (359.82±121.14 vs 231.45±83.76 pg/mL, p<0.001), and lower levels of native thiol (345.23±69.85 vs 395.62±58.71 μmol/L, p<0.001) compared to the normal/mild group. BNP and NT-proBNP levels were moderately elevated in the moderate/severe OSA group (p=0.012 and p=0.003, respectively). Conclusion: IMA, IL-1β, and native thiol demonstrate promise as potential biomarkers for OSA severity. These findings confirm that oxidative stress and inflammation play significant roles in the pathophysi- ology of OSA and offer new opportunities for diagnosis and monitoring.