Effects of a regular exercise program on biochemical parameters of type 2 diabetes mellitus patients

Dincer S., Altanan M., Terzioglu D., Uslu E., Karsidag K., Batu Ş., ...Daha Fazla

Journal of Sports Medicine and Physical Fitness, cilt.56, sa.11, ss.1384-1391, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 56 Sayı: 11
  • Basım Tarihi: 2016
  • Dergi Adı: Journal of Sports Medicine and Physical Fitness
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1384-1391
  • Anahtar Kelimeler: Diabetes mellitus, type 2, Oxidants, Antioxidants, Exercise, Exercise test, OXIDATION PROTEIN PRODUCTS, SIALIC-ACID, CARDIOVASCULAR-DISEASE, ANTIOXIDANT CAPACITY, PHYSICAL-ACTIVITY, GLYCEMIC CONTROL, STRESS, INTERVENTION, METAANALYSIS, RESISTANCE
  • İstanbul Üniversitesi Adresli: Evet

Özet

© 2015 Edizioni Minerva Medica.BACKGROUND: We aimed to investigate the effects of a regular exercise program on exercise capacity, blood biochemical profiles, certain antioxidant and oxidative stress parameters of type 2 Diabetes mellitus (DM) patients. METHODS: Thirty one type 2 DM patients (ages ranging from 42-65 years) who have hemoglobin A1c (HbA1c) levels ≥7.5% and ≤9.5% were included to study and performed two cardiopulmonary exercise tests (CPET) before and after the exercise program. Subjects performed aerobic exercise training for 90 minutes a day; 3 days a week during 12 weeks. Blood samples were collected to analyze certain oxidant and antioxidant parameters (advanced oxidation protein products [AOPP], ferric reducing ability of plasma [FRAP], malondialdehyde [MDA], and sialic acid [SA]), blood lipid profile, fasting blood glucose (FBG) and HbA1c. RESULTS: At the end of the program HbA1c and FBG, triglyceride (TG) and very-low-density lipoprotein (VLDL) levels decreased and high-density lipoprotein (HDL) increased significantly (P=0.000, P=0.001, P=0.008, P=0,001 and P=0.02, respectively). AOPP, FRAP, SA levels of the patients increased significantly following first CPET (P=0.000, P=0.049, P=0.014 respectively). At the end of the exercise program AOPP level increased significantly following last CPET. Baseline SA level increased significantly following exercise program (P=0.002). CONCLUSIONS: We suggest that poor glycemic control which plays the major role in the pathogenesis of DM and its complications would be improved by 12 weeks of a regular exercise program. Whereas the acute exercise induces protein oxidation, regularly aerobic training may enhance the antioxidant status of type 2 DM patients.