Escin’s Action on Bradykinin Pathway: Advantageous Clinical Properties for an Unknown Mechanism?

Marcianò G., Vocca C., Dıraçoğlu D., Sevgin R. Ö., Gallelli L.

Antioxidants, cilt.13, sa.9, 2024 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 13 Sayı: 9
  • Basım Tarihi: 2024
  • Doi Numarası: 10.3390/antiox13091130
  • Dergi Adı: Antioxidants
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, Food Science & Technology Abstracts, Directory of Open Access Journals
  • Anahtar Kelimeler: bradykinin, edema, escin, hippocastanum, inflammation, venous insufficiency
  • İstanbul Üniversitesi Adresli: Evet

Özet

Escin, extracted from horse chestnut (Aesculus hippocastanum) has anti-edema and anti-inflammatory effects. It is used to treat several clinical conditions, including venous insufficiency, pain, inflammation, and edema. Considering escin’s pharmacodynamic, the inhibition of the bradykinin pathway represents a particular effect, decreasing the local edema and conferring an advantage in comparison to other compounds. In this narrative review, we described the effects of escin considering its effects on bradykinin pathway.