The Relationship Between Catechol-O-Methyltransferase Gene Val158Met (COMT) Polymorphism and Premorbid Cannabis Use in Turkish Male Patients with Schizophrenia

Ermis A., Erkiran M., Dasdemir S. , Turkcan A. S. , Ceylan M. E. , Bireller E. S. , ...More

IN VIVO, vol.29, no.1, pp.129-132, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 1
  • Publication Date: 2015
  • Journal Name: IN VIVO
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.129-132
  • Keywords: Schizophrenia, COMT Val158Met, cannabis, VAL(158)MET MODERATION, PSYCHOSIS, ONSET, ASSOCIATION, GENOTYPE, AGE


Background/Aim: One of the risk factors for increasing psychotic disorders is the use of cannabis. It has been shown that the inactivation of dopamine and other catecholamines causes a common polymorphism generating substantial variations in COMT enzyme activity. We aimed to understand the role of cannabis in the etiology of schizophrenia with and without pre-morbid usage. Patients and Methods: The study group consisted of 80 male patients and genotyping of COMT enzyme Val158Met gene polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: It was found that the Val/Val genotype is significantly higher in patients with premorbid cannabis use (88.9%) compared to patients without pre-morbid cannabis use (68.4%). Also, the mean total positive and negative syndrome scale (PANSS) score seen in the Val/Val genotype group is significantly higher than the scores of the patients with the Met allele. Conclusion: The findings from this study confirm the association between COMT Val158 Met polymorphism and pre-morbid cannabis use in causing schizophrenia.