Clinical and magnetic resonance imaging findings of HIV-Negative patients with neurosyphilis

GÜRSES C., Bilgic B., TOPÇULAR B., TUNCER O. G., AKMAN-DEMIR G., HANAGASI H. A., ...Daha Fazla

Journal of Neurology, cilt.254, sa.3, ss.368-374, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 254 Sayı: 3
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1007/s00415-006-0380-z
  • Dergi Adı: Journal of Neurology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.368-374
  • İstanbul Üniversitesi Adresli: Evet

Özet

There have been no serial studies about neuroradiological findings of neurosyphilis in the literature. There have been only case reports concerning HIV negative patients with neurosyphilis. We present 8 HIV negative neurosyphilis patients two of whom are women. The mean age of the patients was 48 years±12.37. Five of the 8 patients had general paresis, two optic atrophy and one multiple cranial neuropathies. The CSF findings were quite similar in 6 of 8 patients. In half of the patients cranial MRI showed mild cerebral atrophy. Nonspecific hyperintense small foci in 3 patients are thought to be related to syphilis. Hyperintensity involving bilateral medial and anterior temporal regions more prominent on the left side was seen in one of the patients with general paresis. This finding may be due to cytotoxic edema associated with status epilepticus and may mimic herpes simplex and other limbic encephalitides. Though not typical, certain MRI findings guides for the diagnosis of neurosyphilis. © 2007 Steinkopff Verlag.