Life-Threatening Hypercalcemia due to Graves' Disease and Concomitant Adrenal Failure: A Case Report and Review of the Literature

Ozkaya H. M., Keskin F. E., Haliloglu O. A., Hayri Şenel T., Kadioglu P.

CASE REPORTS IN ENDOCRINOLOGY, 2015 (ESCI) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası:
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1155/2015/684648
  • Dergi Adı: CASE REPORTS IN ENDOCRINOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • İstanbul Üniversitesi Adresli: Evet

Özet

A 47-year-old woman presented with the complaints of nausea, vomiting, and weight loss. She had a history of bilateral surrenalectomy due to Cushing's syndrome. On examination she had tachycardia and orthostatic hypotension. Laboratory examinations revealed hypercalcemia and suppressed parathyroid hormone levels. She also had thyrotoxicosis due to Graves' disease. The investigations to rule out a malignancy were negative. With steroid, zoledronic acid, and antithyroid drug treatment her symptoms were resolved and calcium level was normalized. This case highlights the importance of recognizing thyrotoxicosis and concomitant adrenal failure as a possible cause of severe hypercalcemia.