Many trace elements have activatory or inhibitory roles in enzyme activities and changes in hemorehology and relation of them with defense system molecules in diseases such as chronic obstructive pulmonary diseases (COPD). Methods: While, 25 male COPD patients (during acute attack) were taken as a Patient Group, another healthy 25 male taken as Control Group. Serum concentrations of copper (Cu), zinc (Zn), and iron (Fe) were determined by atomic absorption spectrophotometer (AA-680 Shimadzu). Results: While decreased Fe (100.00 +/- 36.98; 123.26 +/- 37.58 mu g/dL) (M +/- SD) and Zn (96.31 +/- 31.92; 116.12 +/- 28.17 mu g/dl,) (M +/- SD), while increased Cu (117.92 +/- 25.02; 101.27 +/- 8.29 mu g/dL) (M +/- SD) concentrations were determined in patient samples than that of control group values (p<0.05), (p<0.01). Conclusion: According to findings of present study it may be said that: In organism while trace elements perform their activities on biomaterials they also possible carry out competition against others.