Influence of CPAP treatment on airway and systemic inflammation in OSAS patients

Karamanli H., Ozol D., Ugur K. S., Yildirim Z., Armutcu F., Bozkurt B., ...More

SLEEP AND BREATHING, vol.18, no.2, pp.251-256, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.1007/s11325-012-0761-8
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.251-256
  • Istanbul University Affiliated: No


Obstructive sleep apnea syndrome (OSAS) is characterized by recurrent respiratory disorders in the upper airways during sleep. Although continuous positive airway pressure (CPAP) has been accepted to be the most effective treatment for OSAS, its role on inflammation remains debatable. In this study, our aim was to examine the influence of 3 months of CPAP treatment on tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), 8-isoprostane, and peroxynitrite levels in exhaled breathing condensates (EBC) and serum.