Angiotensin-converting enzyme inhibitor captopril ameliorates renal damage in a rat model of thermal injury

ALTURFAN E. I., Ozdemir G., DAĞOĞLU SAKİN R. N., Ozdamar E. N., Sehirli O., ŞENER G.

ASIAN BIOMEDICINE, vol.7, no.3, pp.381-389, 2013 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.5372/1905-7415.0703.190
  • Journal Name: ASIAN BIOMEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.381-389
  • Keywords: Burn, kidney, captopril, catalase, glutathione, lipid peroxidation, sialic acid, superoxide dismutase, tissue factor, TISSUE LIPID-PEROXIDATION, SUPEROXIDE-DISMUTASE, OXIDATIVE STRESS, N-ACETYLCYSTEINE, BURN INJURY, PLASMA, BLOOD, GLUTATHIONE, PATHWAY, MOUSE
  • Istanbul University Affiliated: Yes

Abstract

Background: Burn is a posttraumatic inflammatory condition accompanied by both local and distant effects leading to intense inflammation, tissue damage, and infection. Acute renal failure is a well-known complication of severe burns and is an important factor leading to an increase in mortality.