Protective effects of N-acetylcysteine and taurine on oxidative stress induced by chronic acetaldehyde administration in rat liver and brain tissues


Yıldız Z. D. , BAKİ A. M. , KÜÇÜKGERGİN C., VURAL P. , ABBASOĞLU S. , UYSAL M.

Archives of Clinical and Experimental Medicine, vol.3, pp.113-117, 2019 (Refereed Journals of Other Institutions)

  • Publication Type: Article / Article
  • Volume: 3
  • Publication Date: 2019
  • Title of Journal : Archives of Clinical and Experimental Medicine
  • Page Numbers: pp.113-117

Abstract

Abstract Aim: Acetaldehyde (AA) is one of the main products of alcohol metabolism. Exposure to AA can occur through ingestion of several dietary products, inhalation of cigarette smoke/automobile exhausts, or contact with cosmetics. AA accumulation causes oxidative stress. The aim of this study was to investigate the prooxidant/antioxidant status in rats chronically exposed to AA, and to evaluate the effects of N-acetylcysteine (NAC) and taurine (TAU) on prooxidant/antioxidant balance. Methods: Sprague Dawley rats were divided in the following groups (n=8; each): Control, AA, AA+NAC, AA+TAU. Reactive oxygen species (ROS), diene conjugate (DC), malondialdehyde (MDA), protein carbonyl (PC), ferric reducing antioxidant power (FRAP) and glutathione (GSH) levels as well as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities were determined in liver and brain tissues. Results: AA treatment in drinking water was detected to induce prooxidant state in both liver and brain of rats. NAC treatment decreased AA-induced prooxidant status in both tissues. Although TAU treatment diminished ROS levels, MDA and PC levels remained unchanged in examined tissues of AA-treated rats. NAC and TAU elevated liver and brain GSH levels in AA-treated rats. Conclusion: Chronic AA administration has created a prooxidant condition, and NAC/TAU appears to be useful in suppression of the developed oxidative stress. Keywords: Acetaldehyde, oxidative stress, N-acetylcysteine, taurine, liver, brain.