A Polysomnographic and Clinical Study of Sleep Disorders in Patients with Behcet and Neuro-Behcet Syndrome

Uygunoglu U., Benbir G., Saip S., Kaynak H., Siva A.

EUROPEAN NEUROLOGY, vol.71, pp.115-119, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 71
  • Publication Date: 2014
  • Doi Number: 10.1159/000355277
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.115-119
  • Istanbul University Affiliated: Yes


Brainstenn is the most common site of involvement in neuro-Behcet syndrome (NBS). On the other hand, the critical importance of this anatomical region in the regulation of sleep has been disregarded in the literature. We aimed to investigate the microstructure of sleep in patients with Behcet syndrome (BS) and NBS. Patients were allocated to 2 groups: (1) BS without any neurological involvement and (2) NBS with brainstem lesions only. A control group was also enrolled in this study. The comparison of polysomnographic parameters between all patients (BS and NBS) with the control group showed that sleep onset was longer (p = 0.006), the duration of superficial NREM sleep stage (N2) was significantly longer (p = 0.018), and the respiratory disturbance index was significantly higher (p = 0.034) in patients. Sleep apnea and restless legs syndrome are more commonly observed in BS and NBS. Our findings emphasize the importance of questioning the quality of sleep and its disorders in patients with BS in order to better handle the common somatic complaints in these patients, such as fatigue or daytime sleepiness. (C) 2014 S. Karger AG, Basel