Decreased levels of cytokines implicate altered immune response in plasma of moderate-stage Alzheimer's disease patients

Koca S., Kiris I., Sahin S., Cinar N., Karsidag S., Hanagasi H. A., ...Daha Fazla

Neuroscience Letters, cilt.786, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 786
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1016/j.neulet.2022.136799
  • Dergi Adı: Neuroscience Letters
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Animal Behavior Abstracts, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Alzheimer ?s Disease (AD), Plasma, Cytokine, Immuno-microarray, Immune response, MILD COGNITIVE IMPAIRMENT, SYSTEMIC INFLAMMATION, MCP-1 LEVELS, MOUSE MODEL, VEGF LEVELS, CHEMOKINES, NEUROINFLAMMATION, EXPRESSION, BIOMARKERS, RANTES
  • İstanbul Üniversitesi Adresli: Evet

Özet

© 2022 Elsevier B.V.Alzheimer's Disease (AD) is a neurodegenerative disease characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain. However, increasing evidence suggests that the pathogenesis of the disease is associated with peripheral inflammation. Here, we aimed to determine plasma concentrations of multiple cytokines and chemokines from moderate-stage AD and age-matched controls. Changes in a total of 20 cytokines and chemokines in plasma of moderate-stage AD were evaluated by using quantitative microarray. Six of them, namely MCP-1, MIP-1a, MIP-1b, MMP-9, RANTES, and VEGF, were found to be significantly reduced in moderate-stage AD patients (n = 25) in comparison to age-matched and non-demented controls (n = 25). However, GM-CSF, GRO-α/β/γ, IFN- γ, IL-1α, IL-1β, IL-10, IL-12 p70, IL-13, IL-2, IL- 4, IL-5, IL-6, IL-8, and TNF-α showed no significant differences between the patient and control groups. On the contrary to previous early-stage AD studies that show increased plasma cytokine/chemokine levels, our results indicate that inflammatory plasma molecules are reduced in moderate-stage AD. This finding points out the reduced immune responsiveness, which is known to be directly correlated to the degree of AD.