Synthesis and isolation of new regioisomeric 4-thiazolidinones and their anticonvulsant activity
TURKISH JOURNAL OF CHEMISTRY, vol.29, no.3, pp.247-254, 2005 (SCI-Expanded, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 29 Issue: 3
- Publication Date: 2005
- Journal Name: TURKISH JOURNAL OF CHEMISTRY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.247-254
- Istanbul University Affiliated: No
Abstract
Two regioisomer series, 2-(3-ethyl-4(3H)-quinazolinone-2-ylmercaptoacetylhydrazono)-3-alkyl/3-aryl-5-methyl-4-thiazolidinones (12-21) and 2-arylimino-3-(3-ethyl-4(3H)-quinazolinone-2-ylmercaptoacetylamino)-5-methyl-4-thiazolidinones (22-26), were synthesized by the cyclization of 1-(3-ethyl-4(3H)-quinazolinone-2-ylmercaptoacetl)-4-alkyl/aryl thiosemicarbazides (1- 11) with ethyl 2-bromopropionate in the presence of anhydrous sodium acetate in anhydrous ethanolic medium. The structures of 12-26 were confirmed by analytical and spectral data (IR, H-1-NMR and EIMS). Selected members of the thiosemicarbazides and thiazolidinones were subjected to anticonvulsant activity tests by the National Institute of Neurological Disorders and Stroke MD, USA.