The Relevance Of Flow Cytometrıc Auto-Crossmatch To The Posttransplant Course Of Kıdney Transplant Recıpıents


Demir E. , Yeğit O. O. , Erol A. , Akgül S. , Çalışkan B., Çalışkan Y. K. , ...More

Türkiye Organ Nakli Kuruluşları Koordinasyon Derneği Xı. Kongresi, Trabzon, Turkey, 13 - 15 October 2016, pp.92

  • Publication Type: Conference Paper / Summary Text
  • City: Trabzon
  • Country: Turkey
  • Page Numbers: pp.92

Abstract

THE RELEVANCE OF FLOW CYTOMETRIC AUTO CROSSMATCH TO THE

POST TRANSPLANT COURSE OF KIDNEY TRANSPLANT RECIPIENTS

Demir E. 1, Yegit O.O. 1, Erol A. 2, Usta Akgul S. 2, Caliskan B. 3, Caliskan Y. 1, Turkmen A.1, Oguz

Savran F. 2, Sever M.Ş. 1

Istanbul Faculty of Medicine, Istanbul University, Division of Nephrology, Department of

Internal Medicine, Istanbul-Turkey 1 Istanbul Faculty of Medicine, Istanbul University,

Department of Medical Biology, Istanbul-Turkey 2 Haseki Training and Research Hospital,

Pediatric Infectious Diseases Unit, Istanbul-Turkey 3

Introduction and aims

The aim of this study was to investigate the effects of flow cytometric auto-crossmatch test on

post-tx events of kidney tx recipients.

Methods

A total of thirty-five patients underwent living renal tx with positive flow cytometric autocross

match test were evaluated. The records of these 35 patients were compared to a control

group including 57 living kidney tx recipients with negative flow cytometric auto-cross match

test [36 (63%) male, mean age:38±11 year]. Post-tx events of the study groups were

evaluated.

Results

The study and control groups were matched with regard to age, gender and time of tx

(p=0.206, p=0.762 and p=0.205, respectively). During the median post-tx follow up of 53.5

(IQR 26.7-83.7) months biopsy confirmed chronic antibody mediated rejection (CAMR) was

developed in 11.4% (n=4) of the patient and 1.8% (n=1) of the control groups (p=0.047). The

patients in the study group had a significantly higher rate of recurrent glomerulonephritis

(GN) after kidney tx (5/11, 46%) compared to control group (1/14, 7.1%) (p=0.026). There

were no differences regarding first (1.24±0.20 vs 1.32±0.37) and 12th months (1.25±0.37 vs

1.27±0.67) serum creatinine levels between study and control groups (p=0.286 and p=0.910,

respectively). The rate of new onset diabetes after tx (NODAT) was significantly higher in

study group (n=7, 20%) compared to controls (n=0, 0%) (p<0.001).

Conslusions

The findings of this study suggest a potential role of auto-antibody causing positive

autocrossmatch

test, meanwhile increasing the risk of CAMR, recurrent GN and NODAT. Further

studies are required to clarify this issue.