Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

Sarwar N., Butterworth A. S., Freitag D. F., Gregson J., Willeit P., Gorman D. N., ...More

LANCET, vol.379, no.9822, pp.1205-1213, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 379 Issue: 9822
  • Publication Date: 2012
  • Doi Number: 10.1016/s0140-6736(11)61931-4
  • Journal Name: LANCET
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1205-1213
  • Istanbul University Affiliated: Yes


Background Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling.