Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

Sarwar N., Butterworth A. S. , Freitag D. F. , Gregson J., Willeit P., Gorman D. N. , ...More

LANCET, vol.379, no.9822, pp.1205-1213, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 379 Issue: 9822
  • Publication Date: 2012
  • Doi Number: 10.1016/s0140-6736(11)61931-4
  • Journal Name: LANCET
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.1205-1213


Background Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling.