Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

Sarwar, Nadeem; Butterworth, Adam; Freitag, Daniel; Gregson, John; Willeit, Peter; Gorman, Donal; Gao, Pei; Saleheen, Danish; Rendon, Augusto; Nelson, Christopher; Braund, Peter; Hall, Alistair; Chasman, Daniel; Tybjaerg-Hansen, Anne; Chambers, John; Benjamin, Emelia; Franks, Paul; Clarke, Robert; Wilde, Arthur; Trip, Mieke; Steri, Maristella; Witteman, Jacqueline; Qi, Lu; van der Schoot, C.; de Faire, Ulf; Erdmann, Jeanette; Stringham, Heather; Koenig, Wolfgang; Rader, Daniel; Melzer, David; Reich, David; Psaty, Bruce; Kleber, Marcus; Panagiotakos, Demosthenes; Willeit, Johann; Wennberg, Patrik; Woodward, Mark; Adamovic, Svetlana; Rimm, Eric; Meade, Tom; Gillum, Richard; Shaffer, Jonathan; Hofman, Albert; Onat, Altan; Sundstrom, Johan; Wassertheil-Smoller, Sylvia; Mellstrom, Dan; Gallacher, John; Cushman, Mary; Tracy, Russell; Kauhanen, Jussi; Karlsson, Magnus; Salonen, Jukka; Wilhelmsen, Lars; Amouyel, Philippe; Cantin, Bernard; Best, Lyle; Ben-Shlomo, Yoav; Manson, JoAnn; Davey-Smith, George; de Bakker, Paul; O'Donnell, Christopher; Wilson, James; Wilson, Anthony; Assimes, Themistocles; Jansson, John-Olov; Ohlsson, Claes; Tivesten, Asa; Ljunggren, Osten; Reilly, Muredach; Hamsten, Anders; Ingelsson, Erik; Cambien, Francois; Hung, Joseph; Thomas, G.; Boehnke, Michael; Schunkert, Heribert; Asselbergs, Folkert; Kastelein, John; Gudnason, Vilmundur; Salomaa, Veikko; Harris, Tamara; Kooner, Jaspal; Allin, Kristine; Nordestgaard, Borge; Hopewell, Jemma; Goodall, Alison; Ridker, Paul; Holm, Hilma; Watkins, Hugh; Ouwehand, Willem; Samani, Nilesh; Kaptoge, Stephen; Di Angelantonio, Emanuele; Harari, Olivier; Danesh, John

doi:10.1016/s0140-6736(11)61931-4

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

Atıf İçin Kopyala

Sarwar N., Butterworth A. S., Freitag D. F., Gregson J., Willeit P., Gorman D. N., ...Daha Fazla

LANCET, cilt.379, sa.9822, ss.1205-1213, 2012 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 379 Sayı: 9822
Basım Tarihi: 2012
Doi Numarası: 10.1016/s0140-6736(11)61931-4
Dergi Adı: LANCET
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1205-1213
İstanbul Üniversitesi Adresli: Evet

Özet

Background Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling.