FLAVONOIDS AND BIOLOGICAL ACTIVITIES OF CENTAUREA NERIMANIAE S. KULTUR


Melikoglu G. , Ozsoy N. , Yilmaz-Ozden T. , Erbay M. S. , Anil S., Celik B. O. , ...Daha Fazla

FARMACIA, cilt.66, ss.1070-1075, 2018 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 66
  • Basım Tarihi: 2018
  • Doi Numarası: 10.31925/farmacia.2018.6.22
  • Dergi Adı: FARMACIA
  • Sayfa Sayıları: ss.1070-1075

Özet

Centaurea nerimaniae S. Kultur, an endemic species from the Turkish flora, distributed in south Anatolia (Icel Province) was investigated for its flavonoids and in vitro antioxidant, anti-cholinergic, anti-inflammatory and antibacterial activities. The phytochemical investigation of the plant led to the isolation of five flavonoids, identified as cirsimaritin, hispidulin, apigenin, isokaempferide and apigenin 7-O-glucoside. In addition to its ability to inhibit AChE and lipid peroxidation, induced by Fe3+/ascorbate system, scavenge DPPH radicals, and to reduce Fe3+ to Fe2+, the extract showed strong COX-1 and COX-2 inhibitory and antimicrobial activities, suggesting that this plant could act as an antioxidant and anti-inflammatory agent against disorders, associated with oxidative damage, as well as an effective phytotherapeutic agent against some fungal and bacterial diseases.