Research Information System
World Journal of Urology, vol.44, no.1, 2026 (SCI-Expanded, Scopus)
Purpose: To investigate the relationship between polyunsaturated fatty acids and biochemical hypogonadism in aging males with a cross-sectional NHANES data. Methods: A total of 1165 men aged ≥ 65 years old, who had complete data on total testosterone levels and erythrocyte membrane fatty acid composition measurements, were included from the National Health and Nutrition Examination Survey (NHANES) 2021–2023 dataset. Biochemical hypogonadism was defined as total testosterone ≤ 300 ng/dL. Age, body mass index (BMI), waist circumference, diabetes mellitus (DM), fatty acid enzyme activities, HDL, LDL, triglycerides, and total cholesterol were also recorded. Results: A total of 1,165 men were analyzed, of whom 859 had complete total testosterone data. In multivariate logistic regression analysis using continuous variables, higher arachidonic acid levels were independently associated with lower odds of biochemical hypogonadism (OR 0.80, 95% CI 0.66–0.97, p = 0.026). Triglyceride levels (OR 1.005, 95% CI 1.001–1.009, p = 0.006) and waist circumference (OR 1.037, 95% CI 1.019–1.056, p < 0.001) were positively associated with biochemical hypogonadism. Diabetes mellitus showed a borderline association with hypogonadism but did not reach statistical significance after adjustment (OR 1.54, 95% CI 0.93–2.56, p = 0.09). HDL cholesterol, palmitoleic acid, docosahexaenoic acid, and linoleic acid were associated with biochemical hypogonadism in univariate analysis but did not remain significant after multivariate adjustment. Conclusion: Arachidonic acid (AA), a component of the omega-6 fatty acid pathway, levels were independently associated with lower odds of biochemical hypogonadism. whereas waist circumference, diabetes mellitus and triglycerides were associated with biochemical hypogonadism.