Suppression of Shivering during Hypothermia Using a Novel Drug Combination in Healthy Volunteers

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Lenhardt R., Orhan-Sungur M., Komatsu R., Govinda R., Kasuya Y., Sessler D. I., ...Daha Fazla

ANESTHESIOLOGY, cilt.111, ss.110-115, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 111
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1097/aln.0b013e3181a979a3
  • Dergi Adı: ANESTHESIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.110-115
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: Hypothermia may be beneficial in stroke victims; however, it provokes vigorous shivering. Buspirone and dexmedetomidine each linearly reduce the shivering threshold with minimal sedation and no respiratory depression. This study tested the hypotheses that the combination of buspirone and dexmedetomidine would (1) synergistically reduce the shivering threshold, (2) synergistically reduce die gain and maximum intensity of shivering, and (3) produce sufficient inhibition to permit cooling to 34 degrees C without excessive hypotension or sedation.