Immunomodulatory effects of Echinacea and Pelargonium on the innate and adoptive immunity in calves

Seckin C., Kalayci G. A., Turan N., Yilmaz A., Cizmecigil U. Y., Aydin O., ...Daha Fazla

FOOD AND AGRICULTURAL IMMUNOLOGY, cilt.29, sa.1, ss.744-761, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1080/09540105.2018.1444738
  • Dergi Adı: FOOD AND AGRICULTURAL IMMUNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.744-761
  • İstanbul Üniversitesi Adresli: Evet

Özet

Immunomodulatory effects of Echinacea purpurae and Pelargonium sidoides in calves were investigated. Sixty 25-day-old nonvaccinated calves living in integrated farm unit were randomly selected and were divided into 5 treatment groups consisting of 12 calves each; 4 groups were receiving different amounts and/or times of Echinacea and Pelargonium and the control group received placebo. Blood levels of gamma-interferon, cytokine gene expression, lactoferrin and total IgG were analysed on days 0, 9, and 30. When levels for total IgG, gamma-interferon, mRNAs for the gamma-interferon, IL-1 beta, IL-4 and the tumour necrosis factor-alpha genes were compared from days 0 to 9 post-treatment, significant differences were found between treated and non-treated calves using various amounts of Echinacea and Pelargonium; a doses of 250 mg Echinacea and 62.5 mg Pelargonium for 5 days seems to be ideal. Echinacea purpurae and Pelargonium sidoides are able to modulate immune functions in calves.