Macrophage migration inhibitory factor in cancer

Yasasever V., Camlica H., Duranyildiz D., Oguz H., Tas F., Dalay N.

CANCER INVESTIGATION, cilt.25, sa.8, ss.715-719, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 8
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1080/07357900701560695
  • Dergi Adı: CANCER INVESTIGATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.715-719
  • Anahtar Kelimeler: MIF, colorectal cancer, malignant melanoma, tumor marker, ELISA, FACTOR MIF, COLORECTAL-CANCER, HEPATOCELLULAR-CARCINOMA, PROSTATIC ADENOCARCINOMA, BREAST-CANCER, CELL-GROWTH, EXPRESSION, ANGIOGENESIS, HYPERSENSITIVITY, MELANOMA
  • İstanbul Üniversitesi Adresli: Evet

Özet

The objective of this study was to investigate the expression of macrophage migration inhibitory factor (MIF) in patients with colorectal cancer (GIS) and malignant melanoma (MM). The study group consists of pathologically verified colorectal cancer (n = 63) and malignant melanoma (n = 65) pateints and healthy controls (n = 25). Serum MIF concentrations were determined by enyzme-linked immunosorbent assay. Serum values of the patients were significantly higher than the controls (p < 0.001 for GIS, p = 0.032 for MM). Diagnostic sensitivity and specificity were calculated for MIF for colorectal and malignant melanoma. The results demonstrate that colorectal cancer express and secrete large amounts of MIF.