Noscapine and diltiazem augment taxol and radiation-induced S-phase arrest and clonogenic death of C6 glioma in vitro


Altinoz M. A., Bilir A., Del Maestro R. F., Tuna S., Ozcan E., Gedikoglu G.

SURGICAL NEUROLOGY, vol.65, no.5, pp.478-485, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 65 Issue: 5
  • Publication Date: 2006
  • Doi Number: 10.1016/j.surneu.2005.06.024
  • Journal Name: SURGICAL NEUROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.478-485
  • Istanbul University Affiliated: No

Abstract

Background: Radiation therapy after surgical resection is the approved treatment of gliomas, and survival benefits are reported with taxane-based chemotherapy. We investigated whether these regimes could be augmented with blood-brain barrier permeable drugs, N and D. Noscapine is an opioid antitussive, which acts anti cancer via blocking microtubule dynamics. Diltiazem is a calcium channel-blocking cardiac antiarrythmic, which also blocks tumor growth and P-glycoprotein.