Noscapine and diltiazem augment taxol and radiation-induced S-phase arrest and clonogenic death of C6 glioma in vitro

Altinoz, Meric; Bilir, Ayhan; Del Maestro, Rolando; Tuna, Sevilcan; Ozcan, Emin; Gedikoglu, Gunduz

doi:10.1016/j.surneu.2005.06.024

Noscapine and diltiazem augment taxol and radiation-induced S-phase arrest and clonogenic death of C6 glioma in vitro

Altinoz M. A., Bilir A., Del Maestro R. F., Tuna S., Ozcan E., Gedikoglu G.

SURGICAL NEUROLOGY, vol.65, no.5, pp.478-485, 2006 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 65 Issue: 5
Publication Date: 2006
Doi Number: 10.1016/j.surneu.2005.06.024
Journal Name: SURGICAL NEUROLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.478-485
Istanbul University Affiliated: No

Abstract

Background: Radiation therapy after surgical resection is the approved treatment of gliomas, and survival benefits are reported with taxane-based chemotherapy. We investigated whether these regimes could be augmented with blood-brain barrier permeable drugs, N and D. Noscapine is an opioid antitussive, which acts anti cancer via blocking microtubule dynamics. Diltiazem is a calcium channel-blocking cardiac antiarrythmic, which also blocks tumor growth and P-glycoprotein.