Sporadic Adrenocorticotropic Hormone-Secreting Lung Carcinoids: Outcomes of Long-Term Clinical Follow-Up at a Single Center
TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM, cilt.26, sa.3, ss.109-114, 2022 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 26 Sayı: 3
- Basım Tarihi: 2022
- Doi Numarası: 10.5152/tjem.2022.22022
- Dergi Adı: TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.109-114
- Anahtar Kelimeler: Ectopic ACTH secretion, lung carcinoids, MEN1 gene, prognosis, NEOPLASIA TYPE-1 MEN1, NEUROENDOCRINE TUMORS, ENDOCRINE, GENE, MUTATIONS, DIAGNOSIS, IDENTIFICATION, MANAGEMENT
- İstanbul Üniversitesi Adresli: Evet
Özet
Objective: Lung carcinoids represent a small portion of all lung tumors and about 1%-5% are associated with ectopic adrenocorticotropic hormone secretion, representing 1%-10% of Cushing's syndrome. They occur both sporadically and rarely in association with multiple endocrine neoplasia type 1. MEN1 variations were detected in approximately 16% of sporadic cases with seldom reports about disease prognosis. This study aimed to identify MEN1 variants in our cohort of sporadic lung carcinoids to associate with disease outcome following surgery.