Sporadic Adrenocorticotropic Hormone-Secreting Lung Carcinoids: Outcomes of Long-Term Clinical Follow-Up at a Single Center

Yarman S., Serbest E., Selcukbiricik O. S., Tuncer F. N.

TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM, vol.26, no.3, pp.109-114, 2022 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 3
  • Publication Date: 2022
  • Doi Number: 10.5152/tjem.2022.22022
  • Journal Name: TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.109-114
  • Keywords: Ectopic ACTH secretion, lung carcinoids, MEN1 gene, prognosis, NEOPLASIA TYPE-1 MEN1, NEUROENDOCRINE TUMORS, ENDOCRINE, GENE, MUTATIONS, DIAGNOSIS, IDENTIFICATION, MANAGEMENT
  • Istanbul University Affiliated: Yes

Abstract

Objective: Lung carcinoids represent a small portion of all lung tumors and about 1%-5% are associated with ectopic adrenocorticotropic hormone secretion, representing 1%-10% of Cushing's syndrome. They occur both sporadically and rarely in association with multiple endocrine neoplasia type 1. MEN1 variations were detected in approximately 16% of sporadic cases with seldom reports about disease prognosis. This study aimed to identify MEN1 variants in our cohort of sporadic lung carcinoids to associate with disease outcome following surgery.