Endothelial nitric oxide synthase intron 4a/b polymorphism and early atherosclerotic changes in hypopituitary GH-deficient adult patients.


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Sen F., Demirturk M., Abaci N. , Golcuk E., Oflaz H., Elitok A. , ...Daha Fazla

European journal of endocrinology, cilt.158, ss.615-22, 2008 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 158 Konu: 5
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1530/eje-07-0704
  • Dergi Adı: European journal of endocrinology
  • Sayfa Sayıları: ss.615-22

Özet

Objective: Endothelial nitric oxide synthase (eNOS) intron 4a/b polymorphism is associated with plasma NO concentrations and coronary artery disease/hypertension in various populations. GH deficiency in adulthood predisposes to reduced NO concentrations and premature atherosclerosis. Our aim was to determine whether intron 4a/b polymorphism of eNOS gene influences endothelial function and early atherosclerotic changes in GH-deficient hypopituitary patients.