Endothelial nitric oxide synthase intron 4a/b polymorphism and early atherosclerotic changes in hypopitutary GH-deficient adult patients
EUROPEAN JOURNAL OF ENDOCRINOLOGY, vol.158, no.5, pp.615-622, 2008 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 158 Issue: 5
- Publication Date: 2008
- Doi Number: 10.1530/eje-07-0704
- Journal Name: EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.615-622
- Istanbul University Affiliated: Yes
Abstract
Objective: Endothelial nitric oxide synthase (eNOS) intron 4a/b polymorphism is associated with plasma NO concentrations and coronary artery disease/hypertension in various populations. GH deficiency in adulthood predisposes to reduced NO concentrations and premature atherosclerosis. Our aim was to determine whether intron 4a/b polymorphism of eNOS gene influences endothelial function and early atherosclerotic changes in GH-deficient hypopituitary patients.