Endothelial nitric oxide synthase intron 4a/b polymorphism and early atherosclerotic changes in hypopitutary GH-deficient adult patients


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Sen F., Demirturk M., Abaci N., Golcuk E., Oflaz H., Elitok A., ...More

EUROPEAN JOURNAL OF ENDOCRINOLOGY, vol.158, no.5, pp.615-622, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 158 Issue: 5
  • Publication Date: 2008
  • Doi Number: 10.1530/eje-07-0704
  • Journal Name: EUROPEAN JOURNAL OF ENDOCRINOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.615-622
  • Istanbul University Affiliated: Yes

Abstract

Objective: Endothelial nitric oxide synthase (eNOS) intron 4a/b polymorphism is associated with plasma NO concentrations and coronary artery disease/hypertension in various populations. GH deficiency in adulthood predisposes to reduced NO concentrations and premature atherosclerosis. Our aim was to determine whether intron 4a/b polymorphism of eNOS gene influences endothelial function and early atherosclerotic changes in GH-deficient hypopituitary patients.