Endothelial nitric oxide synthase intron 4a/b polymorphism and early atherosclerotic changes in hypopitutary GH-deficient adult patients

Sen, Fatma; Demirturk, Mustafa; Abaci, NESLİHAN; Golcuk, Ebru; Oflaz, Huseyin; Elitok, ALİ; Kutluturk, Faruk; Issever, Halim; Unaltuna, Nihan; Ozbey, Nese

doi:10.1530/eje-07-0704

Endothelial nitric oxide synthase intron 4a/b polymorphism and early atherosclerotic changes in hypopitutary GH-deficient adult patients

Sen F., Demirturk M., Abaci N., Golcuk E., Oflaz H., Elitok A., ...Daha Fazla

EUROPEAN JOURNAL OF ENDOCRINOLOGY, cilt.158, sa.5, ss.615-622, 2008 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 158 Sayı: 5
Basım Tarihi: 2008
Doi Numarası: 10.1530/eje-07-0704
Dergi Adı: EUROPEAN JOURNAL OF ENDOCRINOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.615-622
İstanbul Üniversitesi Adresli: Evet

Özet

Objective: Endothelial nitric oxide synthase (eNOS) intron 4a/b polymorphism is associated with plasma NO concentrations and coronary artery disease/hypertension in various populations. GH deficiency in adulthood predisposes to reduced NO concentrations and premature atherosclerosis. Our aim was to determine whether intron 4a/b polymorphism of eNOS gene influences endothelial function and early atherosclerotic changes in GH-deficient hypopituitary patients.