Endothelial nitric oxide synthase intron 4a/b polymorphism and early atherosclerotic changes in hypopitutary GH-deficient adult patients

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Sen F., Demirturk M., Abaci N., Golcuk E., Oflaz H., Elitok A., ...Daha Fazla

EUROPEAN JOURNAL OF ENDOCRINOLOGY, cilt.158, sa.5, ss.615-622, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 158 Sayı: 5
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1530/eje-07-0704
  • Dergi Adı: EUROPEAN JOURNAL OF ENDOCRINOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.615-622
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: Endothelial nitric oxide synthase (eNOS) intron 4a/b polymorphism is associated with plasma NO concentrations and coronary artery disease/hypertension in various populations. GH deficiency in adulthood predisposes to reduced NO concentrations and premature atherosclerosis. Our aim was to determine whether intron 4a/b polymorphism of eNOS gene influences endothelial function and early atherosclerotic changes in GH-deficient hypopituitary patients.