Determining the genome-wide kinship coefficient seems unhelpful in distinguishing consanguineous couples with a high versus low risk for adverse reproductive outcome

Kelmemi, W.; Teeuw, M.; Bochdanovits, Z.; Ouburg, S.; Jonker, M.; Alkuraya, F.; Hashem, M.; Kayserili, H.; van Haeringen, A.; Sheridan, E.; Masri, A.; Cobben, J.; Rizzu, P.; Kostense, P.; Dommering, C.; Henneman, L.; Bouhamed-Chaabouni, H.; Heutink, P.; ten Kate, L.; Cornel, M.

doi:10.1186/s12881-015-0191-0

Determining the genome-wide kinship coefficient seems unhelpful in distinguishing consanguineous couples with a high versus low risk for adverse reproductive outcome

Copy For Citation

Kelmemi W., Teeuw M. E., Bochdanovits Z., Ouburg S., Jonker M. A., Alkuraya F., ...More

BMC MEDICAL GENETICS, vol.16, 2015 (SCI-Expanded)

Publication Type: Article / Article
Volume: 16
Publication Date: 2015
Doi Number: 10.1186/s12881-015-0191-0
Journal Name: BMC MEDICAL GENETICS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Istanbul University Affiliated: Yes

Abstract

Background: Offspring of consanguineous couples are at increased risk of congenital disorders. The risk increases as parents are more closely related. Individuals that have the same degree of relatedness according to their pedigree, show variable genomic kinship coefficients. To investigate whether we can differentiate between couples with high-and low risk for offspring with congenital disorders, we have compared the genomic kinship coefficient of consanguineous parents with a child affected with an autosomal recessive disorder with that of consanguineous parents with only healthy children, corrected for the degree of pedigree relatedness.