Effect of Visible Light on Vasospasticity of Post-Subarachnoid Hemorrhage Cerebrospinal Fluid

Sabanci P. A., Omay B., Aras Y., Aydoseli A., Ali A., ERDEM T., ...Daha Fazla

JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY, cilt.78, sa.6, ss.548-555, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 78 Sayı: 6
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1055/s-0036-1594005
  • Dergi Adı: JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.548-555
  • Anahtar Kelimeler: subarachnoid hemorrhage, cerebral vasospasm, photosensitivity, CSF, BOX, DELAYED CEREBRAL VASOSPASM, OXIDATION-PRODUCTS BOXES, NITRIC-OXIDE SYNTHASE, ASYMMETRIC DIMETHYLARGININE, PRIMATE MODEL, BILIRUBIN, METABOLISM, HYPOTHESIS, THERAPY, CSF
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background and Objective Cerebral vasospasm (CV) is a serious complication of subarachnoid hemorrhage (SAH) with high morbidity and mortality rates. The mechanism of CV has not been determined. There are many theories related to this unsolved issue, one of which supports CV as a two-stage phenomenon from a pathophysiologic perspective. The first stage consists of inhibition of neuronal nitric oxide synthase by oxyhemoglobin, which results in a decrease of nitric oxide (NO) production. The second stage consists of an increase in the levels of asymmetric dimethylarginine through bilirubin oxidation products (BOXes), which are oxidized by-products of hemoglobin metabolism. These in turn inhibit endothelial nitric oxide synthase (eNOS), which results in the blockage of the second NO production mechanism. BOXes are sensitive to visible light, as is their precursor bilirubin. The hypothesis of CV prevention using the photosensitivity of BOXes was tested in this study.