Determination of genetic changes of Rev-erb beta and Rev-erb alpha genes in Type 2 diabetes mellitus by next-generation sequencing

Tokat B., Kanca-Demirci D., Gül N., Satman İ., Ozturk O., Özder A., ...More

GENE, vol.763, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 763
  • Publication Date: 2020
  • Doi Number: 10.1016/j.gene.2020.145058
  • Journal Name: GENE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), Artic & Antarctic Regions, BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Keywords: Type 2 diabetes mellitus, Circadian rhythm, Rev-Erb alpha (NR1D1), Rev-Erb beta (NR1D2), Gene, Next-generation sequencing, CIRCADIAN CLOCK GENE, BODY-SURFACE AREA, ALANINE AMINOTRANSFERASE, METABOLIC SYNDROME, EXPRESSION, OBESITY, RHYTHMS, MICROALBUMINURIA, TRANSCRIPTION, HYPERTENSION
  • Istanbul University Affiliated: Yes

Abstract

Background: The nuclear receptors Rev-erb alpha and Rev-erb beta are transcription factors that regulate the function of genes in glucose and lipid metabolism, and they also form a link between circadian rhythm and metabolism. We evaluated the variations in Rev-erb alpha and Rev-erb beta genes together with biochemical parameters as risk factors in type 2 diabetic (T2DM) patients.