Role and Importance of Vitamin D in Asthma and Other Allergic Diaseases

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Ozdemir O., Karavaizoglu Ç.

JOURNAL OF ACADEMIC RESEARCH IN MEDICINE-JAREM, cilt.8, sa.1, ss.1-8, 2018 (ESCI) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 8 Sayı: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.5152/jarem.2017.1264
  • Dergi Adı: JOURNAL OF ACADEMIC RESEARCH IN MEDICINE-JAREM
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1-8
  • Anahtar Kelimeler: Vitamin D, asthma, allergy, vitamin D receptor, eczema, urticaria, 25-HYDROXYVITAMIN D LEVELS, 3RD NATIONAL-HEALTH, ATOPIC-DERMATITIS, D-RECEPTOR, D SUPPLEMENTATION, D LEVEL, CHILDHOOD ASTHMA, RANDOMIZED-TRIAL, CHILDREN, RISK
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Vitamin D is a steroid hormone that has important effects on bone metabolism and neuromuscular functions. Recent research has indicated that it also has a role in the development and treatment of allergic diseases by affecting the immune system through different mechanisms. After vitamin D is activated by liver and kidney in the body, it shows its effect by attaching to its receptor on the cell membrane. The vitamin D receptor is expressed on all tissue cells, particularly on those of the respiratory and intestinal epithelium by which extra-skeletal functions of vitamin D such as anti-inflammatory effects and immunomodulation are mediated. As a consequence, it is assumed that vitamin D and its receptor have effects on various systems in the human body. Some researchers suggest that deficiency or excess of vitamin D in the diet causes an increase in asthma and allergic diseases. Therefore, vitamin D supplementation is currently advised by some authors for the prevention and treatment of allergic diseases. It has commonly been reported that vitamin D is particularly found to be useful in preventing asthma attack and in managing resistant asthma. Currently, there has been an increase in the literature regarding the role of vitamin D in the treatment of atopic dermatitis and chronic urticaria-angioedema.