Role and Importance of Vitamin D in Asthma and Other Allergic Diaseases

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Ozdemir O., Karavaizoglu Ç.

JOURNAL OF ACADEMIC RESEARCH IN MEDICINE-JAREM, vol.8, no.1, pp.1-8, 2018 (ESCI, TRDizin)

  • Publication Type: Article / Review
  • Volume: 8 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.5152/jarem.2017.1264
  • Journal Name: JOURNAL OF ACADEMIC RESEARCH IN MEDICINE-JAREM
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1-8
  • Keywords: Vitamin D, asthma, allergy, vitamin D receptor, eczema, urticaria, 25-HYDROXYVITAMIN D LEVELS, 3RD NATIONAL-HEALTH, ATOPIC-DERMATITIS, D-RECEPTOR, D SUPPLEMENTATION, D LEVEL, CHILDHOOD ASTHMA, RANDOMIZED-TRIAL, CHILDREN, RISK
  • Open Archive Collection: AVESIS Open Access Collection
  • Istanbul University Affiliated: No

Abstract

Vitamin D is a steroid hormone that has important effects on bone metabolism and neuromuscular functions. Recent research has indicated that it also has a role in the development and treatment of allergic diseases by affecting the immune system through different mechanisms. After vitamin D is activated by liver and kidney in the body, it shows its effect by attaching to its receptor on the cell membrane. The vitamin D receptor is expressed on all tissue cells, particularly on those of the respiratory and intestinal epithelium by which extra-skeletal functions of vitamin D such as anti-inflammatory effects and immunomodulation are mediated. As a consequence, it is assumed that vitamin D and its receptor have effects on various systems in the human body. Some researchers suggest that deficiency or excess of vitamin D in the diet causes an increase in asthma and allergic diseases. Therefore, vitamin D supplementation is currently advised by some authors for the prevention and treatment of allergic diseases. It has commonly been reported that vitamin D is particularly found to be useful in preventing asthma attack and in managing resistant asthma. Currently, there has been an increase in the literature regarding the role of vitamin D in the treatment of atopic dermatitis and chronic urticaria-angioedema.