Discharge patterns in the subthalamic nucleus and substantia nigra during deep brain stimulator implants

Rohr M., Baselli G., Bianchi A., Cerutti S., Tamma F., Caputo E., ...More

23rd Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society, İstanbul, Turkey, 25 - 28 October 2001, vol.23, pp.972-974 identifier identifier

  • Publication Type: Conference Paper / Full Text
  • Volume: 23
  • City: İstanbul
  • Country: Turkey
  • Page Numbers: pp.972-974
  • Keywords: deep brain stimulation, Parkinson's disease, microneurographic recordings, event series analysis
  • Istanbul University Affiliated: No


8 patients affected by Parkinson's disease underwent implantation of stimulating electrodes in both subthalamic nuclei (STN). The stereotactic track was explored by a 1 MOhm microelectrode and recordings were taken at different depths, from 5 mm before down to 5 mm beyond the target, with a 1 mm step. At rest, in 8 out of the 16 successful tracks, spikes were recognizable in correspondence to the STN and in 2 in correspondence to the substantia nigra (SN) beyond the target. Spikes were detected by a matched filtering and threshold algorithm. The spike shape was analyzed by the rise time (0.199+/-0.064 msec, mean+/-SD, in the STN), decay time (0.345+/-0.114 msec) and bandwidth (1.612+/-0.622 kHz, -3dB). The discharge patterns were analyzed through the inter spike interval (ISI) histogram, the conditional intensity function (CIF) and the spectrum of counts. The mean interval was 33.3+/-11.9 msec. Apart a single case of rhythmicity (1.65 Hz), the discharge pattern in the STN was always Poisson like with or without the presence of short bursts, as reveled by a flat C1F. Rhythmic patterns were found in SN.