Panayiotopoulos syndrome and symptomatic occipital lobe epilepsy of childhood: a clinical and EEG study


Tata G. , Guveli B. T. , Dortcan N., Cokar O., Kurucu H., Demirbilek V. , et al.

EPILEPTIC DISORDERS, cilt.16, ss.197-202, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 16 Konu: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1684/epd.2014.0652
  • Dergi Adı: EPILEPTIC DISORDERS
  • Sayfa Sayısı: ss.197-202

Özet

Aim. Panayiotopoulos syndrome (PS) is an age-related seizure susceptibility syndrome that affects the central autonomic system. Although the majority of the few ictal recordings obtained so far suggest an occipital origin, semiological and interictal EEG data appear to favour more extensive involvement. In this study, the characteristics (including those based on semiology and EEG) of children with Panayiotopoulos syndrome (n=24) and those with lesion-related, symptomatic occipital lobe epilepsy (SOLE) (n=23) were compared. Methods. Detailed semiological information and EEG parameters including the localisation, distribution, density (n/sec), reactivity, and morphological characteristics of spike-wave foci and their relationship with different states of vigilance were compared between the two groups. Results. The age at seizure onset was significantly younger in patients with symptomatic occipital lobe epilepsy than in those with PS (mean age at onset: 3.4 versus 5.6 years, respectively; p=0.044). Autonomic seizures (p=0.001) and ictal syncope (p=0.055) were more frequent in PS than in symptomatic occipital lobe epilepsy (87.5% and 37.5% versus 43.5% and 13%, respectively). The interictal spike-wave activity increased significantly during non-rapid eye movement (non-REM) sleep in both groups. The spike waves in non-REM seen in PS tended to spread mainly to central and centro-temporal regions. Conclusions. The results indicate that although common features do exist, Panayiotopoulos syndrome differs from symptomatic occipital lobe epilepsy and has a unique low epileptogenic threshold related to particular brain circuits.
 Aim. Panayiotopoulos syndrome (PS) is an age-related
seizure susceptibility syndrome that affects the central autonomic system.
Although the majority of the few ictal recordings obtained so far suggest an
occipital origin, semiological and interictal EEG data appear to favour more
extensive involvement. In this study, the characteristics (including those
based on semiology and EEG) of children with Panayiotopoulos syndrome
(n=24) and those with lesion-related, symptomatic occipital lobe epilepsy
(SOLE) (n=23) were compared.
Methods. Detailed semiological information and EEG parameters including
the localisation, distribution, density (n/sec), reactivity, and morphological
characteristics of spike-wave foci and their relationship with different states
of vigilance were compared between the two groups.
Results. The age at seizure onset was significantly younger in patients
with symptomatic occipital lobe epilepsy than in those with PS (mean age
at onset: 3.4 versus 5.6 years, respectively; p=0.044). Autonomic seizures
(p=0.001) and ictal syncope (p=0.055) were more frequent in PS than in
symptomatic occipital lobe epilepsy (87.5% and 37.5% versus 43.5% and
13%, respectively). The interictal spike-wave activity increased significantly
during non-rapid eye movement (non-REM) sleep in both groups. The spike
waves in non-REM seen in PS tended to spread mainly to central and centrotemporal
regions.
Conclusions. The results indicate that although common features do
exist, Panayiotopoulos syndrome differs from symptomatic occipital lobe
epilepsy and has a unique low epileptogenic threshold related to particular
brain circuits.