Effects of selective COX-2 inhibitors on the gastric permeability of sucrose: a controlled study with placebo and ibuprofen

Ekenel, Meltem; AVSAR, Emin; IMERYUZ, N; YUKSEL, M; HAKLAR, G; KOCAKAYA, O; TOZUN, N

doi:10.1097/00042737-200304000-00011

Effects of selective COX-2 inhibitors on the gastric permeability of sucrose: a controlled study with placebo and ibuprofen

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Ekenel M., AVSAR E., IMERYUZ N., YUKSEL M., HAKLAR G., KOCAKAYA O., ...More

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, vol.15, no.4, pp.403-406, 2003 (SCI-Expanded)

Publication Type: Article / Article
Volume: 15 Issue: 4
Publication Date: 2003
Doi Number: 10.1097/00042737-200304000-00011
Journal Name: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.403-406
Istanbul University Affiliated: No

Abstract

Objective Acute and chronic use of non-steroidal anti-inflammatory drugs can increase gastrointestinal permeability. Celecoxib, which selectively inhibits the enzyme cyclooxygenase-2, is a novel anti-inflammatory drug with minimal gastrointestinal toxic effects while retaining anti-inflammatory efficacy. Our aim was to assess the potential effects of celecoxib on gastric permeability in comparison with placebo and ibuprofen.