Potent tyrosinase inhibitors from Trifolium balansae
NATURAL PRODUCT RESEARCH, cilt.20, sa.7, ss.665-670, 2006 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 20 Sayı: 7
- Basım Tarihi: 2006
- Doi Numarası: 10.1080/14786410500196821
- Dergi Adı: NATURAL PRODUCT RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.665-670
- İstanbul Üniversitesi Adresli: Hayır
Özet
Trifolium balansae ( Leguminosae) yielded a phytylester, phytyl-1-hexanoate, three steroids, stigmast-5-ene-3 beta,26-diol, stigmast-5-ene-3-ol and campesterol, and an alcohol, pentacosanol which were reported for the first time from T. balansae. The structures of the isolates were determined by 1D and 2DNMR techniques and MS spectroscopy. Compounds 1 - 5 were tested for their enzyme tyrosinase activity. While compounds 1 and 5 did not show any inhibition against the enzyme tyrosinase, compounds 2, 3, and 4 exhibited potent inhibition against tyrosinase. Highly potent ( IC50 = 2.39 mu M) inhibition was found by compound 2, when compared with the standard tyrosinase inhibitors Kojic acid and L-mimosine.